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Research - Keller Group
2020 Mayr, L., Grabherr, F., Schwärzler, J., Reitmeier, I., Sommer, F., Gehmacher, T., Niederreiter, L., He, G. W., Ruder, B., Kunz, K. T. R., Tymoszuk, P., Hilbe, R., Haschka, D., Feistritzer, C., Gerner, R. R., Enrich, B., Przysiecki, N., Seifert, M., Keller, M. A., et al. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease. Nature Communications 11, 1–15 (2020). https://doi.org/10.1038/s41467-020-15646-6 Werner, E. R., Keller, M. A., Sailer, S., Lackner, K., Koch, J., Hermann, M., Coassin, S., Golderer, G., Werner-Felmayer, G.,  Zoeller, R. A., Hulo, N., Berger, J. & Watschinger, K. The TMEM189 gene encodes plasmanylethanolamine desaturase which  introduces the characteristic vinyl ether double bond into plasmalogens. Proceedings of the National Academy of Sciences   201917461 (2020). https://doi.org/10.1073/pnas.1917461117  Michel, M., Dubowy, K.-O., Zlamy, M., Karall, D., Adam, M. G., Entenmann, A., Keller, M. A., Koch, J., Odri Komazec, I.,  Geiger, R., Salvador, C., Niederwanger, C., Müller, U., Scholl-Bürgi, S. & Laser, K. T. Targeted metabolomic analysis of serum  phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle. Therapeutic Advances in Chronic  Disease 11, 204062232091603 (2020). https://doi.org/10.1177/2040622320916031  Oemer, G., Koch, J., Wohlfarter, Y., Alam, M. T., Lackner, K., Sailer, S., Neumann, L., Lindner, H. H., Watschinger, K.,  Haltmeier, M., Werner, E. R., Zschocke, J. & Keller, M. A. Phospholipid Acyl Chain Diversity Controls the Tissue-Specific  Assembly of Mitochondrial Cardiolipins. Cell Reports 30, 4281-4291.e4 (2020). https://doi.org/10.1016/j.celrep.2020.02.115  Huber, A., Galgóczy, L., Váradi, G., Holzknecht, J., Kakar, A., Malanovic, N., Leber, R., Koch, J., Keller, M. A., Batta, G., Tóth,  G. K. & Marx, F. Two small, cysteine-rich and cationic antifungal proteins from Penicillium chrysogenum: A comparative study of PAF and PAFB. Biochimica et Biophysica Acta - Biomembranes 183246 (2020).  https://doi.org/10.1016/j.bbamem.2020.183246  Koch, J., Lackner, K., Wohlfarter, Y., Sailer, S., Zschocke, J., Werner, E. R., Watschinger, K. & Keller, M. A. Unequivocal  mapping of molecular ether lipid species by LC-MS/MS in plasmalogen-deficient mice. bioRxiv 2020.04.29.066530 (2020).  https://doi.org/10.1101/2020.04.29.066530  Oemer, G., Edenhofer, M.-L., Lackner, K., Leman, G., Lindner, H. H., Dubrac, S., Zschocke, J. & Keller, M. A. Fatty Acyl  Availability Modulates Cardiolipin Composition and Alters Mitochondrial Function in HeLa Cells. bioRxiv 2020.02.10.937433  (2020). https://doi.org/10.1101/2020.02.10.937433  2019 Huber, A., Oemer, G., Malanovic, N., Lohner, K., Kovács, L., Salvenmoser, W., Zschocke, J., Keller, M. A. & Marx, F.  Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of Neurospora crassa. Frontiers in  Microbiology 10, 605 (2019). https://doi.org/10.3389/fmicb.2019.00605 Keller, M. A., Kampjut, D., Harrison, S. A., Driscoll, P. C. & Ralser, M. Reply to ‘Do sulfate radicals really enable a non-  enzymatic Krebs cycle precursor?’ Nature ecology & evolution 3, 139–140 (2019). https://doi.org/10.1038/s41559-018-0792-z  Weustenfeld, M., Eidelpes, R., Schmuth, M., Rizzo, W. B., Zschocke, J. & Keller, M. A. Genotype and phenotype variability in  Sjögren-Larsson syndrome. Human Mutation 40, 177–186 (2019). https://doi.org/10.1002/humu.23679  Gnaiger, E., Aasander Frostner, E., Abdul Karim, N., Abumrad, N., Acuna-Castroviejo, D., Adiele, R., Ahn, B., Ali, S., Alton, L.,  Alves, M., Amati, F., Amoedo, N., Andreadou, I., Arago, M., Aral, C., Arandarcikaite, O., Armand, A., Arnould, T., Avram, V., et  al. Mitochondrial respiratory states and rate. (2019). https://doi.org/10.26124/MITOFIT:190001.V2 2018 Zelezniak, A., Vowinckel, J., Capuano, F., Messner, C. B., Demichev, V., Polowsky, N., Mülleder, M., Kamrad, S., Klaus, B.,  Keller, M. A. & Ralser, M. Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase  Knockouts. Cell Systems 7, 269-283.e6 (2018). https://doi.org/10.1016/j.cels.2018.08.001 Keller, M. A., Driscoll, P. C., Messner, C. B. & Ralser, M. 1H-NMR as implemented in several origin of life studies artificially  implies the absence of metabolism-like non-enzymatic reactions by being signal-suppressed. Wellcome Open Research 2, 52  (2018). https://doi.org/10.12688/wellcomeopenres.12103.2 Oemer, G., Lackner, K., Muigg, K., Krumschnabel, G., Watschinger, K., Sailer, S., Lindner, H., Gnaiger, E., Wortmann, S. B.,  Werner, E. R., Zschocke, J. & Keller, M. A. Molecular structural diversity of mitochondrial cardiolipins. Proceedings of the  National Academy of Sciences of the United States of America 115, 4158–4163 (2018).  https://doi.org/10.1073/pnas.1719407115 Werner, E. R., Keller, M. A., Sailer, S., Seppi, D., Golderer, G., Werner-Felmayer, G., Zoeller, R. A. & Watschinger, K. A novel  assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates. Journal of Lipid Research 59, 901–909 (2018). https://doi.org/10.1194/jlr.D080283 Watschinger, K., Keller, M. A., Golderer, G., Coassin, S., Zschocke, J. & Werner, E. R. Biochemical characterization of AGMO  variants implicated in relapses in visceral leishmaniasis. Journal of Infectious Diseases 217, 1846–1847 (2018).  https://doi.org/10.1093/infdis/jiy090 2017 Naschberger, A., Orry, A., Lechner, S., Bowler, M. W., Nurizzo, D., Novokmet, M., Keller, M. A., Oemer, G., Seppi, D., Haslbeck, M., Pansi, K., Dieplinger, H. & Rupp, B. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in  Wnt Transport. Structure 25, 1907-1915.e5 (2017). https://doi.org/10.1016/j.str.2017.10.006 Alam, M. T., Olin-Sandoval, V., Stincone, A., Keller, M. A., Zelezniak, A., Luisi, B. F. & Ralser, M. The self-inhibitory nature of  metabolic networks and its alleviation through compartmentalization. Nature Communications 8, (2017).  https://doi.org/10.1038/ncomms16018 Keller, M. A., Kampjut, D., Harrison, S. A. & Ralser, M. Sulfate radicals enable a non-enzymatic Krebs cycle precursor. Nature  Ecology and Evolution 1, 83–83 (2017). https://doi.org/10.1038/s41559-017-0083 2016 Sheridan, K. J., Lechner, B. E., Keeffe, G. O., Keller, M. A., Werner, E. R., Lindner, H., Jones, G. W., Haas, H. & Doyle, S.  Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Scientific Reports 6, 35306 (2016). https://doi.org/10.1038/srep35306 Keller, M. A., Zylstra, A., Castro, C., Turchyn, A. V, Griffin, J. L. & Ralser, M. Conditional iron and pH-dependent activity of a  non-enzymatic glycolysis and pentose phosphate pathway. Science Advances 2, (2016).  https://doi.org/10.1126/sciadv.1501235 Paglia, G., Stocchero, M., Cacciatore, S., Lai, S., Angel, P., Alam, M. T., Keller, M., Ralser, M. & Astarita, G. Unbiased  Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism.  Journal of Proteome Research 15, 608–618 (2016). https://doi.org/10.1021/acs.jproteome.5b01020 Campbell, K., Vowinckel, J., Keller, M. A. & Ralser, M. Methionine Metabolism Alters Oxidative Stress Resistance via the  Pentose Phosphate Pathway. Antioxidants and Redox Signaling 24, 543–547 (2016). https://doi.org/10.1089/ars.2015.6516 2015 Campbell, K., Vowinckel, J., Mülleder, M., Malmsheimer, S., Lawrence, N., Calvani, E., Miller-Fleming, L., Alam, M. T., Christen, S., Keller, M. A. & Ralser, M. Self-establishing communities enable cooperative metabolite exchange in a eukaryote. eLife 4,  (2015). https://doi.org/10.7554/eLife.09943 Piedrafita, G., Keller, M. A. & Ralser, M. The impact of non-enzymatic reactions and enzyme promiscuity on cellular  metabolism during (Oxidative) stress conditions. Biomolecules 5, 2101–2122 (2015). https://doi.org/10.3390/biom5032101 Jack, C. V, Cruz, C., Hull, R. M., Keller, M. A., Ralser, M. & Houseley, J. Regulation of ribosomal DNA amplification by the TOR pathway. Proceedings of the National Academy of Sciences 112, 9674–9679 (2015). https://doi.org/10.1073/pnas.1505015112 Watschinger, K., Keller, M. A., McNeill, E., Alam, M. T., Lai, S., Sailer, S., Rauch, V., Patel, J., Hermetter, A., Golderer, G., Geley, S., Werner-Felmayer, G., Plumb, R. S., Astarita, G., Ralser, M., Channon, K. M. & Werner, E. R. Tetrahydrobiopterin and  alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Proc. Natl. Acad. Sci. U. S. A. 112,  2431–2436 (2015). https://doi.org/10.1073/pnas.1414887112 Michel, S., Keller, M. A., Wamelink, M. M. C. & Ralser, M. A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance. BMC Genetics 16, (2015). https://doi.org/10.1186/s12863-015-0171-6 Keller, M. A., Piedrafita, G. & Ralser, M. The widespread role of non-enzymatic reactions in cellular metabolism. Current  Opinion in Biotechnology 34, 153–161 (2015). https://doi.org/10.1016/j.copbio.2014.12.020 Timm, K. N., Hartl, J., Keller, M. A., Hu, D. E., Kettunen, M. I., Rodrigues, T. B., Ralser, M. & Brindle, K. M. Hyperpolarized [U-  2H, U-13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells. Magnetic Resonance in Medicine 74, 1543–1547 (2015). https://doi.org/10.1002/mrm.25561 Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin-Sandoval, V., Grüning, N. M., Krüger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D. & Ralser, M. The return of metabolism:  Biochemistry and physiology of the pentose phosphate pathway. Biological Reviews 90, 927–963 (2015). https://doi.org/10.1111/brv.12140 2014 Keller, M. A., Zander, U., Fuchs, J. E., Kreutz, C., Watschinger, K., Mueller, T., Golderer, G., Liedl, K. R., Ralser, M., Kräutler, B., Werner, E. R. & Marquez, J. A. A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme  fatty aldehyde dehydrogenase. Nature Communications 5, 4439 (2014). https://doi.org/10.1038/ncomms5439 Keller, M. A., Turchyn, A. V. & Ralser, M. Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a  plausible Archean ocean. Mol. Syst. Biol. 10, 725 (2014). https://doi.org/10.1002/msb.20145228 Grüning, N. M., Du, D., Keller, M. A., Luisi, B. F. & Ralser, M. Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Open Biology 4, 130232 (2014). https://doi.org/10.1098/rsob.130232 2013 Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. &  Werner, E. R. First insights into structure-function relationships of alkylglycerol monooxygenase. Pteridines 24, 99–103 (2013). https://doi.org/10.1515/pterid-2013-0007 Keller, M. A., Watschinger, K., Golderer, G., Werner-Felmayer, G. & Werner, E. R. Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin- dependent alkylglycerol monooxygenase. Pteridines 24, 105–109 (2013).  https://doi.org/10.1515/pterid-2013-0004 Mayer, M., Keller, M. A., Watschinger, K., Werner-Felmayer, G., Werner, E. R. & Golderer, G. Expression of full-length human  alkylglycerol monooxygenase and fragments in Escherichia coli. Pteridines 24, 111–115 (2013). https://doi.org/10.1515/pterid- 2013-0014  2012 Keller, M. A., Watschinger, K., Lange, K., Golderer, G., Werner-Felmayer, G., Hermetter, A., Wanders, R. J. A. & Werner, E. R.  Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds. Journal of Lipid Research 53, 1410–1416  (2012). https://doi.org/10.1194/jlr.D025650 Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. &  Werner, E. R. Catalytic residues and a predicted structure of tetrahydrobiopterin- dependent alkylglycerol mono-oxygenase. Biochemical Journal 443, 279–286 (2012). https://doi.org/10.1042/BJ20111509 2010 Watschinger, K., Keller, M. A., Golderer, G., Hermann, M., Maglione, M., Sarg, B., Lindner, H. H., Hermetter, A., Werner-  Felmayer, G., Konrat, R., Hulo, N. & Werner, E. R. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proceedings of the National Academy of Sciences of the United States of America 107, 13672–13677 (2010). https://doi.org/10.1073/pnas.1002404107 Keller, M. A., Watschinger, K., Golderer, G., Maglione, M., Sarg, B., Lindner, H. H., Werner-Felmayer, G., Terrinoni, A.,  Wanders, R. J. A. & Werner, E. R. Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from  pyrenedecanal. Journal of Lipid Research 51, 1554–1559 (2010). https://doi.org/10.1194/jlr.D002220 2009 Watschinger, K., Keller, M. A., Golderer, G., Hermetter, A., Maglione, M., Prast, H., Werner-Felmayer, G. & Werner, E. R.  Alkylglycerol monooxygenase: Properties of an orphan enzyme – an update. Pteridines 55–58 (2009). Werner, E. R., Hulo, N., Watschinger, K., Keller, M. A., Golderer, G. & Werner-Felmayer, G. Alkylglycerol monooxygenase  candidate genes - is there a common protein motif for tetrahydrobiopterin interaction? Pteridines 51–54 (2009). at  https://www.researchgate.net/publication/228503259 Keller, M. A., Watschinger, K., Golderer, G., Maglione, M., Werner-felmayer, G. & Werner, E. R. Role of Fatty Aldehyde  Dehydrogenase in Ether Lipid Degradation Pathways. Pteridines 20, 59–63 (2009). Watschinger, K., Keller, M. A., Hermetter, A., Golderer, G., Werner-Felmayer, G. & Werner, E. R. Glyceryl ether  monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence. Biological  chemistry 390, 3–10 (2009). https://doi.org/10.1515/BC.2009.010
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