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Research - Keller Group
2018 Zelezniak A, Vowinckel J, Capuano F, Messner CB,  Demichev V Polowsk N, Mülleder M Kamrad S, Klaus B, Keller MA Ralser M. Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts. Cell Systems (2018) doi: 10.1016/j.cels.2018.08.001 Keller MA, Driscoll PC, Messner C, Ralser M. 1H-NMR as implemented in several origin of life studies artificially implies the absence of metabolism-like non-enzymatic reactions by being signal-suppressed (2018) doi: 10.12688/wellcomeopenres.12103.1 Oemer G, Lackner K, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA. Molecular structural diversity of mitochondrial cardiolipins. Proc. Natl. Acad. Sci. USA (2018) 115 (16), 4158-4163 Werner ER, Keller MA, Sailer S, Seppi D, Golderer G, Werner-Felmayer G, Zoeller RA, Watschinger K. A Novel Assay for the Introduction of the Vinyl Ether Double Bond into Plasmalogens Using Pyrene-Labelled Substrates J. Lipid Res. (2018) doi:10.1194/jlr.D080283 Watschinger K, Keller MA, Golderer G, Coassin S, Zschocke J, Werner ER. Biochemical characterisation of AGMO variants implicated in relapses in visceral leishmaniasis. The Journal of Infectious Diseases (2018) 217(11): 1846–1847. 2017 Naschberger A, Orry A, Lechner S, Bowler MW, Nurizzo D, Novokmet M, Keller MA, Oemer G, Seppi D, Haslbeck M, Pansi K, Dieplinger H, Rupp B. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport, Structure (2017) 25(12) Alam MT, Olin-Sandoval V, Stincone A, Keller MA, Zelezniak A, Luisi BF & Ralser M. The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization. Nature Communications (2017) 8 : 16018 doi:10.1038/ncomms16018 Keller MA, Kampjut D, Harrison SA, Ralser M. Sulfate radicals enable a non-enzymatic Krebs cycle precursor. Nature Ecology & Evolution 1 (2017) 0083 doi:10.1038/s41559-017-0083 2016 Sheridan KJ, Lechner BE, O’Keeffe G, Keller MA, Werner ER, Lindner H, Jones GW, Haas H, Doyle S. Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Scientific Reports. 6 (2016) Keller MA*, Zylstra A, Castro C, Turchyn AV, Griffin JL, Ralser M*. Iron and pH dependency of non-enzymatic reactions enables conditional reactivity in primordially plausible metabolism. Science Advances (2016) DOI: 10.1126/sciadv.1501235 Paglia G, Stocchero M, Cacciatore S, Lai S, Angel PM, Alam MT, Keller MA, Ralser M, Astarita G. An unbiased metabolomic investigation of the Alzheimer’s disease brain points to a dysregulation of the mitochondrial aspartate metabolism. J. Proteome Res. (2016)  DOI: 10.1021/acs.jproteome.5b01020. 2015 Campbell K, Vowinckel J, Keller MA, Ralser M. Methionine metabolism alters oxidative stress resistance via the pentose phosphate pathway. Antioxidants & Redox Signaling (2015) 24(10):543-7. doi: 10.1089/ars.2015.6516. Campbell K, Vowinckel J, Muelleder M, Malmsheimer S, Lawrence N, Calvani E, Miller-Fleming L, Alam TM, Christen S, Keller MA, Ralser M. Self-establishing communities enable cooperative metabolite exchange in a eukaryote. eLife (2015) doi:10.7554/eLife.09943. Piedrafita G*, Keller MA*, Ralser M. The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (oxidative) stress conditions. Biomolecules (2015) 5 (3), 2101-2122 *shared authorship. Jack CV, Cruz C, Hull RM, Keller MA, Ralser M, Houseley J. Regulation of ribosomal DNA amplification by the TOR pathway. Proc. Natl. Acad. Sci. USA (2015) 112(31):9674-9. Watschinger K, Keller MA, McNeill E, Alam MT , Lai S, Sabrina Sailer , Rauch V, Patel J, Hermetter A, Golderer G, Geley G, Werner-Felmayer G, Plumb RS, Astarita G, Ralser M, Channon K, Werner ER. Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Proc. Natl. Acad. Sci. USA (2015) 112(8):2431-6. Michel S, Keller MA, Wamelink MMC, Ralser M. A haploproficient interaction of the alternative transaldolase NQM1 with the transcription factor VHR1 during chronological ageing and oxidative stress response. BMC Genetics (2015) 16:13. Keller MA, Piedrafita G, Ralser M. The widespread role of non-enzymatic reactions in cellular metabolism. Current Opinion in Biotechnology (2015) doi:10.1016/j.copbio.2014.12.020. 2014 Timm KN, Hartl J, Keller MA, Hu D, Ralser M, Brindle KM. Hyperpolarized [U-13C, U-2H2]glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells. Magn Reson Med. (2014) doi: 10.1002/mrm.25561. Stincone A, Prigione A, Cramer T, Wamelink MMC, Campbell K, Cheung E, Olin-Sandoval V, Gruening NM, Krueger A, Alam MT, Keller MA, Breitenbach M, Brindle KM, Rabinowitz JD, Ralser M. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol. Rev. (2014) DOI: 10.1111/brv.12140. Keller MA*, Zander U, Fuchs JE, Kreutz C, Watschinger K, Mueller T, Golderer G, Liedl KR, Ralser M, Kräutler B, Werner ER, Marquez JA*. A gatekeeper helix determines substrate specificity of Sjögren Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nat. Commun. (2014) 5: 4439 *corresponding author. Keller MA, Turchyn A, Ralser M. Spontaneous assembly of a full glycolysis-like pathway in the plausible primeval ocean. Mol Syst Biol. (2014) 10: 725. Grüning NM, Du D, Keller MA, Luisi BF, Ralser M. Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Open Biol. (2014) 4: 130232. 2013 Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER. First Insights into Structure-Function Relationships of Alkylglycerol Monooxygenase. Pteridines (2013) 24(1): 99–103. Keller MA, Watschinger K, Golderer G, Werner-Felmayer G, Werner ER. Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin-dependent alkylglycerol monooxygenase. Pteridines (2013) 24(1): 105–109. Mayer M, Keller MA, Watschinger K, Werner-Felmayer G, Werner ER, Golderer G. Expression of full-length human alkylglycerol monooxygenase and fragments in Escherichia coli. Pteridines (2013) 24(1): 111–115. 2012 Keller MA, Watschinger K, Lange K, Golderer G, Werner-Felmayer G, Hermetter A, Wanders RJA, Werner ER. Studying fatty aldehyde metabolism in living cells with pyrene labeled compounds. J Lipid Res. (2012) 53(7):1410-6. Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER. Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol monooxygenase. Biochem J.  (2012). 443(1): 279-86. 2010 Watschinger K, Keller MA, Golderer G, Hermann M, Maglione M, Sarg B, Lindner H, Hermetter A, Werner-Felmayer G, Konrat R, Hulo N, Werner ER. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proc. Natl. Acad. Sci. USA. (2010) 107 (31): 13672-13677. Keller MA, Watschinger K, Golderer G, Maglione M, Sarg B, Lindner HH, Terrinoni A, Beretta M, Mayer B, Werner-Felmayer G, Werner ER. Monitoring of Fatty Aldehyde Dehydrogenase by Pyrenedecanal. J. Lipid Res. (2010) 51 (6):1554-9. 2009 Keller MA, Watschinger K, Golderer G, Maglione M, Werner-Felmayer G, Werner ER. Role of Fatty Aldehyde Dehydrogenase in Ether Lipid Degradation Pathways. Pteridines (2009) 20(Special issue): 59-63. Watschinger K, Keller MA, Golderer G, Hermetter H, Maglione M, Prast H, Werner-Felmayer G, Werner ER. Alkylglycerol monooxygenase: Properties of an orphan enzyme – an update. Pteridines (2009) 20(Special issue): 55-58. Werner ER, Hulo N, Watschinger K, Keller MA, Golderer G, Werner-Felmayer G. Alkylglycerol monooxygenase candidate genes - is there a common protein motif for tetrahydrobiopterin interaction?. Pteridines (2009) 20(Special issue): 51-54. Watschinger K, Keller MA, Hermetter A, Golderer G, Werner-Felmayer G, Werner ER. Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence. Biol Chem. (2009) 390(1):3-10.
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