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Research - Keller Group
2019 Huber, A., Oemer, G., Malanovic, N., Lohner, K., Kovács, L., Salvenmoser, W., Zschocke, J., Keller, M. A. & Marx, F.  Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of Neurospora crassa. Frontiers in  Microbiology 10, 605 (2019). https://doi.org/10.3389/fmicb.2019.00605 Keller, M. A., Kampjut, D., Harrison, S. A., Driscoll, P. C. & Ralser, M. Reply to ‘Do sulfate radicals really enable a non-  enzymatic Krebs cycle precursor?’ Nature ecology & evolution 3, 139–140 (2019). https://doi.org/10.1038/s41559-018-0792-z Weustenfeld, M., Eidelpes, R., Schmuth, M., Rizzo, W. B., Zschocke, J. & Keller, M. A. Genotype and phenotype variability in Sjögren-Larsson syndrome. Human Mutation 40, 177–186 (2019). https://doi.org/10.1002/humu.23679 2018 Zelezniak, A., Vowinckel, J., Capuano, F., Messner, C. B., Demichev, V., Polowsky, N., Mülleder, M., Kamrad, S., Klaus, B.,  Keller, M. A. & Ralser, M. Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase  Knockouts. Cell Systems 7, 269-283.e6 (2018). https://doi.org/10.1016/j.cels.2018.08.001 Keller, M. A., Driscoll, P. C., Messner, C. B. & Ralser, M. 1H-NMR as implemented in several origin of life studies artificially  implies the absence of metabolism-like non-enzymatic reactions by being signal-suppressed. Wellcome Open Research 2, 52 (2018). https://doi.org/10.12688/wellcomeopenres.12103.2 Oemer, G., Lackner, K., Muigg, K., Krumschnabel, G., Watschinger, K., Sailer, S., Lindner, H., Gnaiger, E., Wortmann, S. B.,  Werner, E. R., Zschocke, J. & Keller, M. A. Molecular structural diversity of mitochondrial cardiolipins. Proceedings of the  National Academy of Sciences of the United States of America 115, 4158–4163 (2018).  https://doi.org/10.1073/pnas.1719407115 Werner, E. R., Keller, M. A., Sailer, S., Seppi, D., Golderer, G., Werner-Felmayer, G., Zoeller, R. A. & Watschinger, K. A novel  assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates. Journal of Lipid Research 59, 901–909 (2018). https://doi.org/10.1194/jlr.D080283 Watschinger, K., Keller, M. A., Golderer, G., Coassin, S., Zschocke, J. & Werner, E. R. Biochemical characterization of AGMO variants implicated in relapses in visceral leishmaniasis. Journal of Infectious Diseases 217, 1846–1847 (2018).  https://doi.org/10.1093/infdis/jiy090 2017 Naschberger, A., Orry, A., Lechner, S., Bowler, M. W., Nurizzo, D., Novokmet, M., Keller, M. A., Oemer, G., Seppi, D.,  Haslbeck, M., Pansi, K., Dieplinger, H. & Rupp, B. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport. Structure 25, 1907-1915.e5 (2017). https://doi.org/10.1016/j.str.2017.10.006 Alam, M. T., Olin-Sandoval, V., Stincone, A., Keller, M. A., Zelezniak, A., Luisi, B. F. & Ralser, M. The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization. Nature Communications 8, (2017).  https://doi.org/10.1038/ncomms16018 Keller, M. A., Kampjut, D., Harrison, S. A. & Ralser, M. Sulfate radicals enable a non-enzymatic Krebs cycle precursor. Nature Ecology and Evolution 1, 83–83 (2017). https://doi.org/10.1038/s41559-017-0083 2016 Sheridan, K. J., Lechner, B. E., Keeffe, G. O., Keller, M. A., Werner, E. R., Lindner, H., Jones, G. W., Haas, H. & Doyle, S.  Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Scientific  Reports 6, 35306 (2016). https://doi.org/10.1038/srep35306 Keller, M. A., Zylstra, A., Castro, C., Turchyn, A. V, Griffin, J. L. & Ralser, M. Conditional iron and pH-dependent activity of a  non-enzymatic glycolysis and pentose phosphate pathway. Science Advances 2, (2016).  https://doi.org/10.1126/sciadv.1501235 Paglia, G., Stocchero, M., Cacciatore, S., Lai, S., Angel, P., Alam, M. T., Keller, M., Ralser, M. & Astarita, G. Unbiased  Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism.  Journal of Proteome Research 15, 608–618 (2016). https://doi.org/10.1021/acs.jproteome.5b01020 Campbell, K., Vowinckel, J., Keller, M. A. & Ralser, M. Methionine Metabolism Alters Oxidative Stress Resistance via the  Pentose Phosphate Pathway. Antioxidants and Redox Signaling 24, 543–547 (2016). https://doi.org/10.1089/ars.2015.6516 2015 Campbell, K., Vowinckel, J., Mülleder, M., Malmsheimer, S., Lawrence, N., Calvani, E., Miller-Fleming, L., Alam, M. T.,  Christen, S., Keller, M. A. & Ralser, M. Self-establishing communities enable cooperative metabolite exchange in a  eukaryote. eLife 4, (2015). https://doi.org/10.7554/eLife.09943 Piedrafita, G., Keller, M. A. & Ralser, M. The impact of non-enzymatic reactions and enzyme promiscuity on cellular  metabolism during (Oxidative) stress conditions. Biomolecules 5, 2101–2122 (2015). https://doi.org/10.3390/biom5032101 Jack, C. V, Cruz, C., Hull, R. M., Keller, M. A., Ralser, M. & Houseley, J. Regulation of ribosomal DNA amplification by the TOR pathway. Proceedings of the National Academy of Sciences 112, 9674–9679 (2015). https://doi.org/10.1073/pnas.1505015112 Watschinger, K., Keller, M. A., McNeill, E., Alam, M. T., Lai, S., Sailer, S., Rauch, V., Patel, J., Hermetter, A., Golderer, G.,  Geley, S., Werner-Felmayer, G., Plumb, R. S., Astarita, G., Ralser, M., Channon, K. M. & Werner, E. R. Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Proc. Natl. Acad. Sci. U. S. A. 112,  2431–2436 (2015). https://doi.org/10.1073/pnas.1414887112 Michel, S., Keller, M. A., Wamelink, M. M. C. & Ralser, M. A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance. BMC Genetics 16, (2015). https://doi.org/10.1186/s12863-015-0171-6  Keller, M. A., Piedrafita, G. & Ralser, M. The widespread role of non-enzymatic reactions in cellular metabolism. Current  Opinion in Biotechnology 34, 153–161 (2015). https://doi.org/10.1016/j.copbio.2014.12.020 Timm, K. N., Hartl, J., Keller, M. A., Hu, D. E., Kettunen, M. I., Rodrigues, T. B., Ralser, M. & Brindle, K. M. Hyperpolarized [U- 2H, U-13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in  yeast cells. Magnetic Resonance in Medicine 74, 1543–1547 (2015). https://doi.org/10.1002/mrm.25561 Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin-Sandoval, V., Grüning, N. M.,  Krüger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D. & Ralser, M. The return of  metabolism: Biochemistry and physiology of the pentose phosphate pathway. Biological Reviews 90, 927–963 (2015). https://doi.org/10.1111/brv.12140 2014 Keller, M. A., Zander, U., Fuchs, J. E., Kreutz, C., Watschinger, K., Mueller, T., Golderer, G., Liedl, K. R., Ralser, M., Kräutler, B., Werner, E. R. & Marquez, J. A. A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature Communications 5, 4439 (2014). https://doi.org/10.1038/ncomms5439 Keller, M. A., Turchyn, A. V. & Ralser, M. Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a  plausible Archean ocean. Mol. Syst. Biol. 10, 725 (2014). https://doi.org/10.1002/msb.20145228 Grüning, N. M., Du, D., Keller, M. A., Luisi, B. F. & Ralser, M. Inhibition of triosephosphate isomerase by  phosphoenolpyruvate in the feedback-regulation of glycolysis. Open Biology 4, 130232 (2014). https://doi.org/10.1098/rsob.130232 2013 Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. &  Werner, E. R. First insights into structure-function relationships of alkylglycerol monooxygenase. Pteridines 24, 99–103  (2013). https://doi.org/10.1515/pterid-2013-0007 Keller, M. A., Watschinger, K., Golderer, G., Werner-Felmayer, G. & Werner, E. R. Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin- dependent alkylglycerol monooxygenase. Pteridines 24, 105–109 (2013).  https://doi.org/10.1515/pterid-2013-0004 Mayer, M., Keller, M. A., Watschinger, K., Werner-Felmayer, G., Werner, E. R. & Golderer, G. Expression of full-length human alkylglycerol monooxygenase and fragments in Escherichia coli. Pteridines 24, 111–115 (2013).  https://doi.org/10.1515/pterid-2013-0014 2012 Keller, M. A., Watschinger, K., Lange, K., Golderer, G., Werner-Felmayer, G., Hermetter, A., Wanders, R. J. A. & Werner, E. R. Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds. Journal of Lipid Research 53, 1410–1416 (2012). https://doi.org/10.1194/jlr.D025650 Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. &  Werner, E. R. Catalytic residues and a predicted structure of tetrahydrobiopterin- dependent alkylglycerol mono-oxygenase. Biochemical Journal 443, 279–286 (2012). https://doi.org/10.1042/BJ20111509 2010 Watschinger, K., Keller, M. A., Golderer, G., Hermann, M., Maglione, M., Sarg, B., Lindner, H. H., Hermetter, A., Werner-  Felmayer, G., Konrat, R., Hulo, N. & Werner, E. R. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proceedings of the National Academy of Sciences of the United  States of America 107, 13672–13677 (2010). https://doi.org/10.1073/pnas.1002404107 Keller, M. A., Watschinger, K., Golderer, G., Maglione, M., Sarg, B., Lindner, H. H., Werner-Felmayer, G., Terrinoni, A.,  Wanders, R. J. A. & Werner, E. R. Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from  pyrenedecanal. Journal of Lipid Research 51, 1554–1559 (2010). https://doi.org/10.1194/jlr.D002220 2009 Watschinger, K., Keller, M. A., Golderer, G., Hermetter, A., Maglione, M., Prast, H., Werner-Felmayer, G. & Werner, E. R.  Alkylglycerol monooxygenase: Properties of an orphan enzyme – an update. Pteridines 55–58 (2009). Werner, E. R., Hulo, N., Watschinger, K., Keller, M. A., Golderer, G. & Werner-Felmayer, G. Alkylglycerol monooxygenase  candidate genes - is there a common protein motif for tetrahydrobiopterin interaction? Pteridines 51–54 (2009). at  https://www.researchgate.net/publication/228503259 Keller, M. A., Watschinger, K., Golderer, G., Maglione, M., Werner-felmayer, G. & Werner, E. R. Role of Fatty Aldehyde  Dehydrogenase in Ether Lipid Degradation Pathways. Pteridines 20, 59–63 (2009). Watschinger, K., Keller, M. A., Hermetter, A., Golderer, G., Werner-Felmayer, G. & Werner, E. R. Glyceryl ether  monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence. Biological chemistry 390, 3–10 (2009). https://doi.org/10.1515/BC.2009.010
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